A Mild and Green
Method for the N-BOC Protection of Amines without Assistant of Catalyst Under
Solvent-free Conditions
Author(s):
Mohammad Majid Mojtahedi, Nina Niknejad and
Hojat Veisi Pages 121 - 125 ( 5 )
Abstract:
A facile, green and versatile method for the
Boc protection of amines has been developed by a treatment with (Boc)2O without any additive at room temperature. The method is
general for the preparation of N-Boc derivatives of aliphatic (acyclic and
cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The
advantages of this method are green, simplicity, short reaction times and
excellent yields.
Keywords:
N-BOC protection, green, catalyst-free,
solvent-free
Affiliation:
Department of Chemistry, Payame Noor
University (PNU), 19395-4697 Tehran, Iran.
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